Treatment Of Sepsis With Vitamin C
The vitamin c thiamine and steroids in sepsis victas study is a double blind placebo controlled adaptive randomized clinical trial being conducted at 43 academic centers.
Treatment of sepsis with vitamin c. Sepsis related organ failure assessment scores decreased for all patients in the treatment group and none developed progressive organ failure. Fowler s team found that four days of infusions with vitamin c reduced a patient s risk of death within a month of treatment from 46 to. In addition emerging evidence suggests that the combination of vitamin c corticosteroids and thiamine may act synergistically to reverse sepsis induced organ dysfunction. When marik encountered a sepsis patient who seemed on the verge of death he decided to give her vitamin c.
He added thiamine a b vitamin and a dose of steroids to her treatment. In experimental sepsis models intravenous vitamin c reduces organ injury and improves survival. Sepsis is associated with an acute deficiency of vitamin c. More recently vitamin c has emerged as a potential therapeutic agent to treat sepsis.
During the treatment period consecutive patients with a primary admitting diagnosis of severe sepsis or septic shock and a pct level 2 ng ml were treated with intravenous vitamin c 1 5 g every 6 h for 4 days or until icu discharge hydrocortisone 50 mg every 6 h for 7 days or until icu discharge followed by a taper over 3 days as well as intravenous thiamine 200 mg every 12 h for 4 days or until icu discharge. Blood pressure plunges and widespread organ failure follows. Cleveland clinic researchers are also a part of a multicenter study assessing the role of vitamin c in treatment of patients with sepsis in victas. Vitamin c has been shown to be deficient in septic patients and the administration of high dose intravenous as opposed to oral vitamin c leads to markedly improved and elevated serum levels.
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